反应详情

温度

0 °C

3-Oxopentanoic acid (II in Scheme 1; Example 1.1; 2 g; 17.2 mmol) was dissolved in 30 ml THF and cooled to 0° C. To the solution, was added dicarbodiimidazole (3.6 g; 22.2 mmol; Aldrich). The reaction mixture was stirred for 18 h at 25° C., neutralized with 2% HCl, extracted with 3×30 ml EtOAc, dried with anhydrous Na2SO4, and evaporated to a white solid. The product was purified via silica chromatography (20% EtOAc in hexanes).

1. additionTo the solution, was added dicarbodiimidazole (3.6 g; 22.2 mmol; Aldrich)
2. extractionextracted with 3×30 ml EtOAc
3. dry with materialdried with anhydrous Na2SO4
4. customevaporated to a white solid
5. customThe product was purified via silica chromatography (20% EtOAc in hexanes)