反应详情

1.00 g (3.96 mmol) of 2-amino-4-phenyl-6-sulfanylpyridine-3,5-dicarbonitrile (Example 30A), 0.96 g (4.36 mmol) of 4-(chloromethyl)-N-methylpyridine-2-carboxamide hydrochloride (Example 41A) and 1.33 g (15.84 mmol) of sodium bicarbonate were dissolved in 20 ml of DMF and the mixture was stirred at RT for 2 h. 500 ml of water were added to the reaction mixture. The precipitate was filtered off and washed with water.

1. filtrationThe precipitate was filtered off
2. washwashed with water