反应详情

To a stirred solution of (±) epicatechin 1 (0.10 gm, 0.34 mmol) in DMF, Acetic anhydride (0.11 ml, 0.10 mmol) and pyridine (0.08 ml, 0.10 mmol) was added at room temperature. After an additional stirring at this for 24 h, 2N HCl was added and extracted with ethyl acetate (2×50 ml). The combined organic layer was washed with brine and dried over sodium sulphate. The crude reaction mixture was purified using preparative HPLC to afford 4-((2R,3R)-3,5,7-trihydroxychroman-2-yl)-1,2-phenylene diacetate (0.004 gm) and 4-((2R,3R)-3,5,7-trihydroxychroman-2-yl)-1,2-phenylene diacetate (0.008 gm) as a white solid material.

1. extractionextracted with ethyl acetate (2×50 ml)
2. washThe combined organic layer was washed with brine
3. dry with materialdried over sodium sulphate
4. customThe crude reaction mixture
5. customwas purified