Hydrochloric Acid → HCID 117840434, compound

HRID 714824Notes

Reaction equation

HRID 714824 reaction equation
[C:1]([C@@:3]1([CH:31]2[CH2:33][CH2:32]2)[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:16]=[N:17][N:18]([C:20]([CH3:29])([CH3:28])[C:21]([O:23]C(C)(C)C)=[O:22])[CH:19]=3)[N:9]=2)[C:4]1=[O:30])#[N:2].[ClH:34]>C(OCC)(=O)C>[ClH:34].[C:1]([C@@:3]1([CH:31]2[CH2:32][CH2:33]2)[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:16]=[N:17][N:18]([C:20]([CH3:29])([CH3:28])[C:21]([OH:23])=[O:22])[CH:19]=3)[N:9]=2)[C:4]1=[O:30])#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117840337HCID 117840337, compound

Product 1

HCID 117840434HCID 117840434, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of tert-butyl 2-(4-((4-((3S)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-2-methylpropanoate (1.0 g) obtained in Step C of Example 108 in ethyl acetate (10 mL) was added a solution of 4 M hydrogen chloride in ethyl acetate (10 mL), and the mixture was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure, and the residue was recrystallized (diisopropyl ether/ethanol) to give the crude title compound (1.1 g).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was recrystallized (diisopropyl ether/ethanol)

Sources & evidence

ORD record
ord-f77b84e1e15e45568089320a5cd71b64
Source dataset
uspto-grants-2015_11
Patent number
US09187453B2

Reaction notes

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