Hydrochloric Acid → 2-(4-nitro-1H-pyrazol-1-yl)ethan-1-amine hydrochloride

HRID 714900Notes

Reaction equation

HRID 714900 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[N:11]1)(C)(C)C.[ClH:19]>C(OCC)(=O)C>[ClH:19].[N+:15]([C:13]1[CH:12]=[N:11][N:10]([CH2:9][CH2:8][NH2:7])[CH:14]=1)([O-:17])=[O:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70984700tert-butyl (2-(4-nitro-1H-pyrazol-1-yl)ethyl)carbamate

Product 1

HCID 717566062-(4-nitro-1H-pyrazol-1-yl)ethan-1-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of tert-butyl(2-(4-nitro-1H-pyrazol-1-yl)ethyl)carbamate (8.0 g) obtained in Step A of Example 348 in ethyl acetate (30 mL) was added a solution of 4 M hydrogen chloride in ethyl acetate (4.0 mL), and the mixture was stirred at room temperature for 3 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (4.7 g).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c059066c643b47f7a17ed4c9abae15d6
Source dataset
uspto-grants-2015_11
Patent number
US09187453B2

Reaction notes

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