Hydrochloric Acid → HCID 89875049, compound

HRID 715319Notes

Reaction equation

HRID 715319 reaction equation
[CH2:1]([NH:3][C:4]([C:6]1[C:11]2[CH2:12][N:13]([CH2:16][C:17]3[CH:29]=[CH:28][C:20]([C:21]([O:23]C(C)(C)C)=[O:22])=[C:19]([CH3:30])[CH:18]=3)[C:14](=[O:15])[C:10]=2[CH:9]=[CH:8][N:7]=1)=[O:5])[CH3:2].[ClH:31]>O1CCOCC1>[ClH:31].[CH2:1]([NH:3][C:4]([C:6]1[C:11]2[CH2:12][N:13]([CH2:16][C:17]3[CH:29]=[CH:28][C:20]([C:21]([OH:23])=[O:22])=[C:19]([CH3:30])[CH:18]=3)[C:14](=[O:15])[C:10]=2[CH:9]=[CH:8][N:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89874442HCID 89874442, compound

Product 1

HCID 89875049HCID 89875049, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl 4-((4-(ethylcarbamoyl)-1-oxo-1H-pyrrolo[3,4-c]pyridin-2(3H)-yl)methyl)-2-methylbenzoate (260 mg, 0.64 mmol, Step-3) in 4 M hydrogen chloride in dioxane (20 mL) is stirred overnight at rt. The mixture is concentrated to give 220 mg (89% yield) of the title compound as pale brown solid.

Workup

  1. concentrationThe mixture is concentrated

Sources & evidence

ORD record
ord-bc506fc0c6274ecba5b7f549920f7ffc
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

Loading…