Phthalimide → HCID 89874903, compound

HRID 715424Notes

Reaction equation

HRID 715424 reaction equation
[F:1][CH:2]([F:14])[CH2:3][O:4][C:5]1[C:6]([CH3:13])=[CH:7][C:8]([CH2:11]O)=[N:9][CH:10]=1.[C:15]1(=[O:25])[NH:19][C:18](=[O:20])[C:17]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]12.CCCCCCCCCCCCN>>[F:1][CH:2]([F:14])[CH2:3][O:4][C:5]1[C:6]([CH3:13])=[CH:7][C:8]([CH2:11][N:19]2[C:15](=[O:25])[C:16]3[C:17](=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:18]2=[O:20])=[N:9][CH:10]=1

Participants

4

Reactant 3

HCID 6809PhthalimideHCID 13583DodecylamineHCID 89874622HCID 89874622, compound

Product 1

HCID 89874903HCID 89874903, compoundYield 74%

Procedure

The title compound is prepared in 74% yield (720 mg, white solid) from (5-(2,2-difluoroethoxy)-4-methylpyridin-2-yl)methanol (594 mg, 2.92 mmol, Step-3) and phthalimide (473 mg, 3.22 mmol) in a similar manner to Step-4 of Amine-12.

Sources & evidence

ORD record
ord-51684ea7c4024c398308e2b547273311
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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