Potassium Carbonate → HCID 58072035, compound

HRID 715681Notes

Reaction equation

HRID 715681 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:12][CH3:13])[C:10]=1[OH:11])[C:6]#[N:7].C(=O)([O-])[O-].[K+].[K+].Cl.Cl[CH2:22][CH2:23][N:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>CC(N(C)C)=O>[CH3:13][O:12][C:9]1[CH:8]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:10]=1[O:11][CH2:22][CH2:23][N:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1)[C:6]#[N:7]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)HCID 14381935Benzonitrile, 4-hydroxy-3,5-dimethoxy-

Product 1

HCID 58072035HCID 58072035, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Conditions

Temperature
100 °C

Procedure

6.06 g 3,5 Dimethoxy-4-hydroxy-benzonitrile was dissolved in 20 mL dimethylacetamide, 5.2 g potassium carbonate and 6.7 g N-(2-chloroethyl)morpholine hydrochloride was added and the mixture was stirred at 100° C. for 6 h. The solvent was distilled off and the residue was co-evaporated twice with toluene. The residue was suspended in dichloromethane, filtered and the filtrate was concentrated.

Workup

  1. distillationThe solvent was distilled off
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-60eefaa9a4d54537b88b922c4caa9d20
Source dataset
uspto-grants-2015_11
Patent number
US09187478B2

Reaction notes

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