Potassium Carbonate → HCID 16577665, compound

HRID 715684Notes

Reaction equation

HRID 715684 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[O:10][CH3:11].C(=O)([O-])[O-].[K+].[K+].[CH3:18][O:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24]Br)=[CH:22][CH:21]=1>CN(C)C=O.ClCCl.O>[CH3:11][O:10][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:2]=1[O:1][CH2:24][C:23]1[CH:26]=[CH:27][C:20]([O:19][CH3:18])=[CH:21][CH:22]=1)[C:6]#[N:7]

Participants

7

Reactant 3

HCID 11430Potassium CarbonateHCID 781354-Hydroxy-3-methoxybenzonitrileHCID 1650214-Methoxybenzyl bromide

Product 1

HCID 16577665HCID 16577665, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

3.73 g 4-Hydroxy-3-methoxybenzonitrile was dissolved in dimethylformamide and 3.8 g potassium carbonate was added before the mixture was stirred for 15 min. 5 g para-Methoxybenzylbromide was added and stirring was continued for 1 h. The mixture was diluted with dichloromethane and water. The phases were separated and the water phase extracted again with dichloromethane. The combined organic phases were dried over magnesium sulfate and concentrated.

Workup

  1. stirringstirring
  2. waitwas continued for 1 h
  3. customThe phases were separated
  4. extractionthe water phase extracted again with dichloromethane
  5. dry with materialThe combined organic phases were dried over magnesium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-19f6b3260eec476fabe4ead105203cee
Source dataset
uspto-grants-2015_11
Patent number
US09187478B2

Reaction notes

Loading…