Triethylamine → HCID 565655, compound

HRID 716666Notes

Reaction equation

HRID 716666 reaction equation
[CH2:1]([NH2:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH2:9].C(N([CH2:16][CH3:17])CC)C.[O:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[C:23](Cl)=[O:24]>CN(C1C=CN=CC=1)C>[CH2:1]([NH:10][C:23]([C:19]1[O:18][CH:22]=[CH:16][CH:17]=1)=[O:24])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH:9][C:23]([C:19]1[O:18][CH:22]=[CH:21][CH:20]=1)=[O:24]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 242501,8-OctanediamineHCID 682422-Furancarbonyl chloride

Product 1

HCID 565655HCID 565655, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

The general procedure was carried out using 1,8-octanediamine (10.0 g, 69.3 mmol), triethylamine (14.2 g, 141 mmol), DMAP (0.17 g, 1.35 mmol) and furoyl chloride (19.0 g, 146 mmol). The resulting compound was purified by column chromatography (98:2 DCM:EtOAc), and the product obtained as a white solid (21.5 g/92%).

Workup

  1. customThe resulting compound was purified by column chromatography (98:2 DCM:EtOAc)
  2. customthe product obtained as a white solid (21.5 g/92%)

Sources & evidence

ORD record
ord-5b557948ae2d444d9a515bf35fb36572
Source dataset
uspto-grants-2015_11
Patent number
US09193139B2

Reaction notes

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