Diethyl Malonate → Ethyl 1-(cyclopropylmethyl)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate

HRID 716686Notes

Reaction equation

HRID 716686 reaction equation
[CH:1]1([CH2:4][N:5]2[C:11](=[O:12])[O:10][C:8](=O)[C:7]3=[CH:13][CH:14]=[CH:15][CH:16]=[C:6]23)[CH2:3][CH2:2]1.[H-].[Na+].C(OCC)(=O)[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[CH:1]1([CH2:4][N:5]2[C:6]3[C:7](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:8]([OH:10])=[C:20]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:11]2=[O:12])[CH2:2][CH2:3]1

Participants

4

Procedure

Reagents: Comp 20 (1.38 mmols, 0.3 g); Sodium hydride (2.91 mmols, 0.07 g); Diethyl malonate (6.91 mmols, 1.1 g).

Sources & evidence

ORD record
ord-2eac71d6dd5a426f97e2253f8a095af9
Source dataset
uspto-grants-2015_11
Patent number
US09193688B2

Reaction notes

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