Hydrochloric Acid → HCID 90269097, compound

HRID 717213Notes

Reaction equation

HRID 717213 reaction equation
[C:1]1([C:7]2[CH:11]=[C:10]([CH2:12][O:13][C:14]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[N:17]=[CH:16][N:15]=3)[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:24]>CO>[ClH:24].[C:1]1([C:7]2[CH:11]=[C:10]([CH2:12][O:13][C:14]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[N:17]=[CH:16][N:15]=3)[O:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71761597HCID 71761597, compound

Product 1

HCID 90269097HCID 90269097, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.5 mmol of 4-((3-phenyl-isoxazol-5-yl)-methoxy-)-quinazoline was added in 20 mL mixing solution of 5% hydrochloric acid solution and methanol (V:V=1:1), and dissolved by stirring under slightly heating. The mixture was slowly evaporated and crystallized at room temperature to afford 4-((3-phenyl-isoxazol-5-yl)-methoxy-)-quinazoline hydrochloride as a white solid in 68% yield.

Workup

  1. dissolutiondissolved
  2. temperatureunder slightly heating
  3. customThe mixture was slowly evaporated
  4. customcrystallized at room temperature

Sources & evidence

ORD record
ord-58b53271aa634e619b2382f1f0d4e04a
Source dataset
uspto-grants-2015_11
Patent number
US09193718B2

Reaction notes

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