Hydrochloric Acid → HCID 66992779, compound

HRID 717838Notes

Reaction equation

HRID 717838 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([Cl:26])[C:7]2[N:8]([CH:23]=[N:24][CH:25]=2)[C:9]=1[N:10]1[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]1)(=[O:3])[CH3:2].Cl.O1CCOCC1>>[ClH:26].[Cl:26][C:6]1[C:7]2[N:8]([CH:23]=[N:24][CH:25]=2)[C:9]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[C:4]([C:1](=[O:3])[CH3:2])[CH:5]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 58515955HCID 58515955, compound

Product 1

HCID 66992779HCID 66992779, compoundYield 199.1%

Procedure

tert-Butyl 4-(6-acetyl-8-chloroimidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxylate (19 mg, 0.051 mmol) was taken into a vial and 4.0 M hydrogen chloride in 1,4-dioxane (1.0 mL, 4.0 mmol) was added and was stirred for 15 minutes. The solvents were evaporated to give the desired compound (16 mg, quantitative). LCMS calculated for C13H16ClN4O (M+H)+: m/z=279.1. found: 278.9.

Workup

  1. additionwas added
  2. customThe solvents were evaporated

Sources & evidence

ORD record
ord-cb25477e57dc449fa430bff5a9eb21a4
Source dataset
uspto-grants-2015_11
Patent number
US09193721B2

Reaction notes

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