反应详情

The ethyl (1Z)—N-[(mesitylsulfonyl)oxy]ethanimidoate (5.0 g, 18 mmol) was dissolved in 1,4-dioxane (4.5 mL, 58 mmol) and cooled in an ice bath under nitrogen. Perchloric acid (2.3 mL, 38 mmol) was added drop wise over 3 minutes. The reaction slowly became a thick mixture after 20 minutes. Ice (50 mL) was added to the reaction. The reaction was extracted with ethyl ether. The combined organic layer was washed with brine, dried over potassium carbonate (solid) and the volume was reduced to about 40 mL. LCMS calculated for C9H14NO3S (M+H)+: m/z=216.0. found: 215.9.

1. temperaturecooled in an ice bath under nitrogen
2. customThe reaction
3. customafter 20 minutes
4. extractionThe reaction was extracted with ethyl ether
5. washThe combined organic layer was washed with brine
6. dry with materialdried over potassium carbonate (solid)