Hydrochloric Acid → HCID 86702005, compound

HRID 717978Notes

Reaction equation

HRID 717978 reaction equation
C([O:3][C:4]([C:6]1[S:10][C:9]([CH:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]2)=[CH:8][CH:7]=1)=[O:5])C.[OH-].[Na+].CO.Cl>O1CCCC1.O>[C:20]([O:19][C:17]([N:14]1[CH2:13][CH2:12][CH:11]([C:9]2[S:10][C:6]([C:4]([OH:5])=[O:3])=[CH:7][CH:8]=2)[CH2:16][CH2:15]1)=[O:18])([CH3:23])([CH3:21])[CH3:22]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 86702006HCID 86702006, compound

Product 1

HCID 86702005HCID 86702005, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

In a 250 mL round bottom flask was mixed tert-butyl 4-(5-(ethoxycarbonyl)thiophen-2-yl)piperidine-1-carboxylate (5.00 g, 14.73 mmol) in tetrahydrofuran (50 ml). Aqueous 4N NaOH (38.41 ml, 73.6 mmol) solution was added along with some methanol (10 ml) to get a single phase solution. The mixture was stirred overnight at room temperature. The solvents were removed to give a white slurry that was diluted with water and adjusted to pH of 5 with 1N aqueous hydrochloric acid. Filtration provided the title compound.

Workup

  1. customto get a single phase solution
  2. customThe solvents were removed
  3. customto give a white slurry that
  4. filtrationFiltration

Sources & evidence

ORD record
ord-93410b81c45842ba89c13a3ac4131a28
Source dataset
uspto-grants-2015_11
Patent number
US09193723B2

Reaction notes

Loading…