Hydroxylamine → HCID 90074011, compound

HRID 718011Notes

Reaction equation

HRID 718011 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[NH2:14][OH:15].CO>O1CCCC1.C(O)C>[Cl:1][C:2]1[CH:9]=[CH:8][C:5](/[CH:6]=[N:14]/[OH:15])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11]

Participants

6

Reactant 3

HCID 787HydroxylamineHCID 887MethanolHCID 1186424-Chloro-3-(trifluoromethyl)benzaldehyde

Product 1

HCID 90074011HCID 90074011, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 4-chloro-3-(trifluoromethyl)benzaldehyde (93.9 mg, 0.45 mmol) in tetrahydrofuran (0.9 mL) and ethanol (0.9 mL) was added hydroxylamine (50% in water, 0.20 mL) and the reaction was maintained at room temperature for 36 hours. Methanol (3.0 mL) was added, the solvent was removed in vacuo, and the residue was triturated with toluene (2×1 mL) to afford the title compound as a solid. Yield: 101 mg, 0.45 mmol, 100%.

Workup

  1. customthe solvent was removed in vacuo
  2. customthe residue was triturated with toluene (2×1 mL)

Sources & evidence

ORD record
ord-ba48a489185c40d584d1b9981ea89a3e
Source dataset
uspto-grants-2015_11
Patent number
US09193726B2

Reaction notes

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