HRID718062

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2C(c1ccccc1)c1ccccc1

HCID70672817

未命名化合物

PRODUCTS

生成物

结构：Cl.Cl.c1ccc(C(c2ccccc2)N2C[C@@H]3C[C@H]2CN3)cc1

HCID67006897

未命名化合物

收率 59%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A solution of compound 200 (0.5 g, 1.37 mmol) in 4N HCl in dioxane (5 mL) was stirred for 1 h at room temperature and then concentrated. The residue was purified by trituration with Et2O and filtered to afford 201 (0.24 g, 59%) as a beige solid. LRMS (ESI): (calc) 264.2. (found) 265.3 (MH)+.

WORKUP

后处理

concentrationconcentrated
customThe residue was purified by trituration with Et2O
filtrationfiltered