反应详情

温度

125 °C

A mixture of ethyl 2-aminothiophene-3-carboxylate (0.5 g, 3.18 mmol), chloroformamidine hydrochloride (0.91 g, 7.95 mmol) and dimethylsulfone (1.50 g, 15.9 mmol) was heated at 120-130° C. for 30 minutes. After cooling down to room temperature, water (10 ml) was added and ammonium hydroxide was used to neutralize the suspension. The solid was filtered off, washed with water and dried. The crude residue was purified by flash chromatography on silica gel (CH2Cl2/MeOH 10:1) to yield the title compound as a white solid (0.24 g, 45%).

1. temperatureAfter cooling down to room temperature
2. filtrationThe solid was filtered off
3. washwashed with water
4. customdried
5. customThe crude residue was purified by flash chromatography on silica gel (CH2Cl2/MeOH 10:1)