Triphenylphosphine → HCID 118307785, compound

HRID 718443Notes

Reaction equation

HRID 718443 reaction equation
[C:1]([O:5][C@@H:6]([C:12]1[C:13]([CH3:34])=[N:14][C:15]([CH3:33])=[C:16]([C:26]2[CH:31]=[CH:30][C:29](O)=[CH:28][CH:27]=2)[C:17]=1[N:18]1[CH2:23][CH2:22][C:21]([CH3:25])([CH3:24])[CH2:20][CH2:19]1)[C:7]([O:9]CC)=[O:8])([CH3:4])([CH3:3])[CH3:2].[CH:35]1[C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[CH:38]=[CH:37][C:36]=1[CH2:45][CH2:46][OH:47].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.CCOC(/N=N/C(OCC)=O)=O.[OH-].[Na+]>C1COCC1.CO>[C:1]([O:5][C@@H:6]([C:12]1[C:13]([CH3:34])=[N:14][C:15]([CH3:33])=[C:16]([C:26]2[CH:27]=[CH:28][C:29]([O:47][CH2:46][CH2:45][C:36]3[CH:37]=[CH:38][C:39]4[C:44](=[CH:43][CH:42]=[CH:41][CH:40]=4)[CH:35]=3)=[CH:30][CH:31]=2)[C:17]=1[N:18]1[CH2:19][CH2:20][C:21]([CH3:25])([CH3:24])[CH2:22][CH2:23]1)[C:7]([OH:9])=[O:8])([CH3:4])([CH3:2])[CH3:3]

Participants

8

Reactant 5

HCID 11776TriphenylphosphineHCID 14798Sodium HydroxideHCID 738772-NaphthaleneethanolHCID 5462977Diethyl azodicarboxylateHCID 118314205(S)-ethyl 2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin-1-yl)-5-(4-hydroxyphenyl)-2,6-dimethylpyridin-3-yl)acetate

Product 1

HCID 118307785HCID 118307785, compoundYield 10.64%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of (S)-ethyl 2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin-1-yl)-5-(4-hydroxyphenyl)-2,6-dimethylpyridin-3-yl)acetate (20 mg, 0.043 mmol), 2-(naphthalen-2-yl)ethanol (36.8 mg, 0.213 mmol) and Ph3P-resin (55.8 mg, 0.213 mmol) in THF (2 mL) was added DEAD (0.014 mL, 0.085 mmol) at rt. After 18 h, mixture was filtered to remove polymer, concentrated and treated with 1N NaOH (0.854 mL, 0.854 mmol) in MeOH (1 mL) at 75° C. for 16 h. Mixture was then cooled and purified by prep-HPLC to afford (S)-2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin-1-yl)-2,6-dimethyl-5-(4-(2-(naphthalen-2-yl)ethoxy)phenyl)pyridin-3-yl)acetic acid (2.7 mg, 4.54 μmol, 10.64% yield). 1H NMR (500 MHz, DMSO-d6) δ 7.92-7.80 (m, 4H), 7.57-7.46 (m, 3H), 7.21 (d, J=8.4 Hz, 1H), 7.10-6.93 (m, 3H), 5.83 (s, 1H), 4.45-4.26 (m, 2H), 3.45-3.24 (m, 3H), 2.80 (t, J=11.2 Hz, 1H), 2.43 (s, 3H), 2.17 (br. s., 1H), 2.05 (s, 3H), 1.99-1.91 (m, 1H), 1.48 (br. s., 1H), 1.37-1.27 (m, 1H), 1.17 (d, J=13.9 Hz, 1H), 1.12 (s, 9H), 1.02 (d, J=11.7 Hz, 1H), 0.84 (s, 3H), 0.60 (s, 3H). LCMS (M+H)=595.5.

Workup

  1. filtrationmixture was filtered
  2. customto remove polymer
  3. concentrationconcentrated
  4. temperatureMixture was then cooled
  5. custompurified by prep-HPLC

Sources & evidence

ORD record
ord-8be4dfb113b948b38b32f7316705e99e
Source dataset
uspto-grants-2015_11
Patent number
US09193720B2

Reaction notes

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