Trifluoroacetic acid → HCID 117728382, compound

HRID 718592Notes

Reaction equation

HRID 718592 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:16]3[N:17]=[CH:18][CH:19]=[C:20]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)[C:15]3=N[C:13]=2[CH:27]2[CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28]2)=[CH:8][CH:7]=1)=[O:5])[CH3:2].[C:38]([OH:44])([C:40]([F:43])([F:42])[F:41])=[O:39]>C(Cl)Cl>[F:41][C:40]([F:43])([F:42])[C:38]([OH:44])=[O:39].[NH:29]1[CH2:28][CH:27]([C:13]2[CH:38]=[C:15]3[C:20]([N:21]4[CH2:22][CH2:23][O:24][CH2:25][CH2:26]4)=[CH:19][CH:18]=[N:17][N:16]3[C:12]=2[C:9]2[CH:8]=[CH:7][C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[CH:11][CH:10]=2)[CH2:30]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117732468HCID 117732468, compound

Product 1

HCID 117728382HCID 117728382, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 19e (170 mg, 0.335 mmol) in DCM (2 mL), TFA (2 mL) was added. The resulting mixture was stirred at rt for 1 h and concentrated. The resulting residue was dried in vacuo for 4 h and suspended in ether. The mixture was concentrated and the resulting residue was dried in vacuo overnight to obtain ethyl 4-(6-(azetidin-3-yl)-4-morpholinopyrrolo[1,2-b]pyridazin-7-yl)benzoate trifluoro acetic acid salt (19g), which was used without further purification in the next step.

Workup

  1. concentrationconcentrated
  2. customThe resulting residue was dried in vacuo for 4 h
  3. concentrationThe mixture was concentrated
  4. customthe resulting residue was dried in vacuo overnight

Sources & evidence

ORD record
ord-4d0992702a29442390c46c4fe37dc38f
Source dataset
uspto-grants-2015_11
Patent number
US09193736B2

Reaction notes

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