Lithium hydroxide, monohydrate → 2-(2-(Benzylcarbamoyl)-1-methylhydrazinyl)acetic acid

HRID 718885Notes

Reaction equation

HRID 718885 reaction equation
[CH2:1]([N:4]([CH2:16][C:17]([O:19]CC)=[O:18])[NH:5][C:6](=[O:15])[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)C=C.O.[OH-].[Li+]>>[CH2:8]([NH:7][C:6]([NH:5][N:4]([CH2:16][C:17]([OH:19])=[O:18])[CH3:1])=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 59541461Ethyl 2-(1-allyl-2-(benzylcarbamoyl)hydrazinyl)acetate

Product 1

HCID 533974892-(2-(Benzylcarbamoyl)-1-methylhydrazinyl)acetic acidYield 88.5%

Procedure

According to the procedure described in the synthesis method of Compound VI-2 with the modification that the reaction was carried out overnight, ethyl 2-(1-allyl-2-(benzylcarbamoyl)hydrazinyl)acetate (Compound V-2) 1.33 g (5.0 mmol) was reacted with lithium hydroxide monohydrate 420 mg (10.0 mmol) to obtain the title compound 1.05 g (88%).

Workup

  1. customdescribed in the synthesis method of Compound VI-2 with the modification that the reaction

Sources & evidence

ORD record
ord-34be39171bbe46d381f393b19a0e2ba8
Source dataset
uspto-grants-2015_11
Patent number
US09193734B2

Reaction notes

Loading…