反应详情

A mixture of 5-methoxy-[1,2]naphthoquinone (prepared by treatment of 5-methoxytetralone with selenium dioxide, A. Bekaert et al Tetrahedron Letters 38, 24, 4219–4220, 1997) (1.98 g), 2,3-diamino-benzoic acid, diacetate salt, (J. Chem. Soc. Perkin. Trans I, 1984, p2019) (4.03 g) and conc. hydrochloric acid (2.2 mL) was heated to reflux in ethanol (20 mL) for 4 hours. The reaction mixture was cooled and the precipitate collected by filtration, and washed with ethanol and ether to yield the title compound as a beige solid (2.74 g).

1. temperatureThe reaction mixture was cooled
2. filtrationthe precipitate collected by filtration
3. washwashed with ethanol and ether