Trifluoroacetic acid → HCID 69596867, compound

HRID 719194Notes

Reaction equation

HRID 719194 reaction equation
C([O:5][C:6](=[O:35])[CH2:7][O:8][C:9]1[C:14]2=[CH:15][CH:16]=[C:17]3[C:26]([N:25]=[C:24]4[C:19]([CH:20]=[CH:21][CH:22]=[C:23]4[C:27](=[O:34])[NH:28][CH2:29][CH2:30][N:31]([CH3:33])[CH3:32])=[N:18]3)=[C:13]2[CH:12]=[CH:11][CH:10]=1)(C)(C)C.[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]>ClCCl>[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39].[CH3:32][N:31]([CH3:33])[CH2:30][CH2:29][NH:28][C:27]([C:23]1[C:24]2[C:19](=[N:18][C:17]3[C:26]([N:25]=2)=[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([O:8][CH2:7][C:6]([OH:35])=[O:5])[C:14]2=[CH:15][CH:16]=3)[CH:20]=[CH:21][CH:22]=1)=[O:34]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11102819HCID 11102819, compound

Product 1

HCID 69596867HCID 69596867, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of [11-(2-dimethylamino-ethylcarbamoyl)-benzo[a]phenazin-4-yloxy]-acetic acid tert-butyl ester (18 mg) in dry dichloromethane (1 mL) was added trifluoroacetic acid (1 mL). After stirring for 4 hours the solvent was removed in vacuo to yield crude product. This was triturated with ether to yield the title compound as a yellow solid (10 mg).

Workup

  1. customwas removed in vacuo
  2. customto yield crude product
  3. customThis was triturated with ether

Sources & evidence

ORD record
ord-fa7e7d7ad8594ce7b90d5774b3d9029a
Source dataset
uspto-grants-2006_11
Patent number
US07132419B2

Reaction notes

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