Phosphorus oxychloride → HCID 178424623, compound

HRID 719284Notes

Reaction equation

HRID 719284 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][CH:22]=1)[C:5]([NH:7][C:8]1[C:9]([CH3:19])=[N:10][NH:11][C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=O.P(Cl)(Cl)(Cl)=O>ClCCl.CO>[CH3:19][C:9]1[C:8]2[N:7]=[C:5]([C:4]3[CH:20]=[CH:21][CH:22]=[C:2]([CH3:1])[CH:3]=3)[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[C:12]=2[NH:11][N:10]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178425291HCID 178425291, compound

Product 1

HCID 178424623HCID 178424623, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The preparation took place in analogy to example 34 (D) using 404 mg of 3-methyl-N-(3-methyl-5-phenyl-1H-pyrazol-4-yl)-benzamide, except 10 ml of phosphorous oxychloride was used and the reaction was stirred for 4 hrs. Trituration of the residue with dichloromethane/methanol (95/5) gave the title compound as an off white solid.

Sources & evidence

ORD record
ord-cd563462dfaa401987bdb713cd097805
Source dataset
uspto-grants-2006_11
Patent number
US07132428B2

Reaction notes

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