Phosphorus oxychloride → HCID 178434200, compound

HRID 719285Notes

Reaction equation

HRID 719285 reaction equation
[Br:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[C:4]([NH:6][C:7]1[C:8]([CH3:18])=[N:9][NH:10][C:11]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O.P(Cl)(Cl)(Cl)=O>>[Br:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[C:4]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:11]2[NH:10][N:9]=[C:8]([CH3:18])[C:7]=2[N:6]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178434572HCID 178434572, compound

Product 1

HCID 178434200HCID 178434200, compound

Procedure

The preparation took place in analogy to example 34 (D) using 196 mg of 2-bromo-N-(3-methyl-5-phenyl-1H-pyrazole-4-yl)-benzamide, except 6 ml of phosphorous oxychloride was used and the reaction was stirred for 4 hrs. The residue was triturated with dichloromethane to give the title compound as a white solid.

Workup

  1. customThe residue was triturated with dichloromethane

Sources & evidence

ORD record
ord-c68bb2271e0942acb8d64272f7d40ad5
Source dataset
uspto-grants-2006_11
Patent number
US07132428B2

Reaction notes

Loading…