反应详情

4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid was prepared as described for 4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid. 4′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester (3.75 g, 9.55 mmol, 1 eq.) in 30% aqueous THF was reacted with lithium hydroxide (0.69 g, 28.65 mmol, 3 eq.). When complete, the reaction was worked up as described leaving a light yellow solid which was recrystallized from acetone/diethyl ether to afford 4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid (2.28 g, 65% yield) as a light yellow solid.

1. custom4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid was prepared
2. customas described leaving a light yellow solid which
3. customwas recrystallized from acetone/diethyl ether