反应详情

4′-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid ethyl ester was prepared as described for 4′-(2-hydroxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl ester. 4′-Bromomethyl-biphenyl-2-carboxylic acid ethyl ester (4.1 g, 12.84 mmol, 1 eq.) in anhydrous DMF was treated with 2-mercaptoethanol (1.2 g, 15.41 mmol, 1.2 eq.) and potassium carbonate (5.32 g, 38.52 mmol, 3 eq.). When complete, the reaction was worked up and purified as described for 4′-(2-hydroxy-ethylsulfanylmethyl)-biphenyl4-carboxylic acid ethyl ester to leave 4′-(2-hydroxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid ethyl ester (3.05 g, 42% yield) as a light yellow oil.

1. custom4′-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid ethyl ester was prepared
2. custompurified