反应详情

3′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid was synthesized as described for 4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid. 3′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid ethyl ester (2.1 g, 5.35 mmol, 1 eq.) in 30% aqueous THF was treated with lithium hydroxide (0.38 g, 16.05 mmol, 3 eq.). When complete, the reaction was worked up as described leaving 3′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid (1.94, 99% yield) as a yellow oil.

1. custom3′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid was synthesized