反应详情

3′-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl ester was synthesized as described for 4′-(2-hydroxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl ester. 3′-Bromomethyl-biphenyl-3-carboxylic acid ethyl ester (3.4 g, 10.65 mmol, 1 eq.) in anhydrous DMF was treated with 2-mercaptoethanol (1.0g, 12.78 mmol, 1.2 eq.) and potassium carbonate (4.42 g, 31.95 mmol, 3 eq.). When complete, the reaction was worked up as described leaving a yellow oil.

1. customas described leaving a yellow oil