反应详情

2′-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl ester was synthesized as described for 4′-(2-hydroxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl ester. 2′-Bromomethyl-biphenyl-3-carboxylic acid ethyl ester (10.3 g, 32.27 mmol, 1 eq.) in anhydrous DMF was treated with 2-mercaptoethanol (3.03 g, 38.72 mmol, 1.2 eq.) and potassium carbonate (13.38 g, 96.81 mmol, 3 eq.). When complete, the reaction was worked up as described leaving a yellow/orange oil.

1. customas described leaving a yellow/orange oil