反应详情

2′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid was synthesized as described for 4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid. 2′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl ester (3.65 g, 9.30 mmol, 1 eq.) in 30% aqueous THF was treated with lithium hydroxide (0.67 g, 27.9 mmol, 3 eq.). When complete, the reaction was worked up as described leaving 2′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid (3.39 g, 100% yield) as an off-white solid.

1. custom2′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid was synthesized