N,N-Dimethylethylenediamine → 2'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid (2-dimethylamino-ethyl)-amide

HRID 719727Notes

Reaction equation

HRID 719727 reaction equation
CN(C)CCCNC(C1C=C(C2C=CC(CSCCOC3C=CC=CC=3)=CC=2)C=CC=1)=O.[O:33]([CH2:40][CH2:41][S:42][CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=1[C:50]1[CH:55]=[CH:54][CH:53]=[C:52]([C:56](O)=[O:57])[CH:51]=1)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1.[CH3:59][N:60]([CH3:64])[CH2:61][CH2:62][NH2:63]>C1COCC1>[CH3:59][N:60]([CH3:64])[CH2:61][CH2:62][NH:63][C:56]([C:52]1[CH:51]=[C:50]([C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][C:44]=2[CH2:43][S:42][CH2:41][CH2:40][O:33][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:55]=[CH:54][CH:53]=1)=[O:57]

Participants

5

Reactant 3

HCID 66053N,N-DimethylethylenediamineHCID 103471824'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid(3-dimethylamino-propyl)-amideHCID 218999962'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid

Product 1

HCID 100983242'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid (2-dimethylamino-ethyl)-amide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid (2-dimethylamino-ethyl)-amide was synthesized as described for 4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid (3-dimethylamino-propyl)-amide. 2′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid (1.0 g, 2.74 mmol, 1 eq.) in anhydrous THF was treated with 1,1-carbonyldiimidazole (0.45 g, 2.79 mmol, 1.02 eq.) followed by N,N-dimethylethylenediamine (0.29 g, 3.29 mmol, 1.2 eq.) as described. When complete, the reaction was worked up as described leaving a yellow oil.

Workup

  1. customas described leaving a yellow oil

Sources & evidence

ORD record
ord-387132e34f0e44258f27a13806f414dd
Source dataset
uspto-grants-2006_11
Patent number
US07132456B2

Reaction notes

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