Anisole → 5-Chloro-1-(4-methoxyphenyl)pentan-1-one

HRID 719786Notes

Reaction equation

[C:1]1([O:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14](Cl)=[O:15]>>[Cl:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([C:4]1[CH:5]=[CH:6][C:1]([O:7][CH3:8])=[CH:2][CH:3]=1)=[O:15]

Participants

Reactant 2

HCID 7519Anisole

HCID 740895-Chlorovaleryl chloride

Product 1

HCID 127094845-Chloro-1-(4-methoxyphenyl)pentan-1-one

Procedure

Using anisole (15.0 g) and 5-chlorovaleryl chloride (18.0 ml) according to the same method as that of Reference Example 1, the title compound was obtained as colorless crystals (27.3 g) having a melting point of 67 to 68° C.

Sources & evidence

ORD record: ord-33df468fbd0a4150811d87fb4f54cf4e
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07132547B2

Reaction notes

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