Methacryloyl chloride → N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methylprop-2-enamide

HRID 719847Notes

Reaction equation

[C:1]([C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][C:4]=1[C:10]([F:13])([F:12])[F:11])#[N:2].[C:14](Cl)(=[O:18])[C:15]([CH3:17])=[CH2:16]>>[C:14]([NH:7][C:6]1[CH:8]=[CH:9][C:3]([C:1]#[N:2])=[C:4]([C:10]([F:11])([F:12])[F:13])[CH:5]=1)(=[O:18])[C:15]([CH3:17])=[CH2:16]

Participants

Reactant 2

HCID 13528Methacryloyl chloride

HCID 5221704-Amino-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11149469N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methylprop-2-enamide

Procedure

Using 4-cyano-3-trifluoromethylaniline and methacryloyl chloride as starting materials, the title compound is prepared according to the method described in J. Med. Chem., 1988, 954–959.

Sources & evidence

ORD record: ord-1957e7558bbf4f8aa9d0d0efc30570f5
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07132560B2

Reaction notes

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