Trifluoroacetic acid → HCID 137241990, compound

HRID 720091Notes

Reaction equation

HRID 720091 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15](=[O:37])[NH:16][C:17]2[CH:18]=[C:19]3[C:35](=[O:36])[NH:34][N:33]=[CH:32][C:21]4=[C:22]([C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=5)[NH:23][C:24]([CH:25]=2)=[C:20]34)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:38]([OH:44])([C:40]([F:43])([F:42])[F:41])=[O:39]>C(Cl)Cl>[F:41][C:40]([F:43])([F:42])[C:38]([OH:44])=[O:39].[O:36]=[C:35]1[C:19]2[C:20]3[C:21](=[C:22]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[NH:23][C:24]=3[CH:25]=[C:17]([NH:16][C:15](=[O:37])[CH2:14][CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:18]=2)[CH:32]=[N:33][NH:34]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 136181670HCID 136181670, compound

Product 1

HCID 137241990HCID 137241990, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Preparation of example 32 from the title compound of Example 30 (31 mg, 0.062 mmol) and 45% TFA in CH2Cl2 (1 mL) was carried out analogously to Example 20. Isolation, also in an analogous manner, afforded the title compound (29 mg, 0.056 mmol) as a yellow powder in 91% yield.

Sources & evidence

ORD record
ord-94c7965f14df44e8acc39631ee83359a
Source dataset
uspto-grants-2006_11
Patent number
US07132533B2

Reaction notes

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