Hydrochloric Acid → HCID 136401843, compound

HRID 720143Notes

Reaction equation

HRID 720143 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C@@H:12]([NH:30]C(=O)OC(C)(C)C)[C:13](=[O:29])[NH:14][C:15]1[CH:16]=[C:17]2[C:27](=[O:28])[NH:26][N:25]=[CH:24][C:19]3=[CH:20][NH:21][C:22]([CH:23]=1)=[C:18]23.[ClH:38]>O1CCOCC1>[ClH:38].[NH2:30][C@H:12]([CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[C:13]([NH:14][C:15]1[CH:16]=[C:17]2[C:27](=[O:28])[NH:26][N:25]=[CH:24][C:19]3=[CH:20][NH:21][C:22]([CH:23]=1)=[C:18]23)=[O:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136181624HCID 136181624, compound

Product 1

HCID 136401843HCID 136401843, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Preparation of example 179 from the title compound of Example 158 (57 mg, 0.115 mmol) and 4M HCl in dioxane (10 mL) was carried out analogously to Example 91. Isolation, also in an analogous manner afforded the title compound (48 mg, 0.111 mmol) as an orange/yellow powder in 97% yield.

Sources & evidence

ORD record
ord-440146f661244fe281defdd7834d1516
Source dataset
uspto-grants-2006_11
Patent number
US07132533B2

Reaction notes

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