Hydrochloric Acid → HCID 136341287, compound

HRID 720146Notes

Reaction equation

HRID 720146 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C@@H:9]([NH:27]C(=O)OC(C)(C)C)[C:10](=[O:26])[NH:11][C:12]2[CH:13]=[C:14]3[C:24](=[O:25])[NH:23][N:22]=[CH:21][C:16]4=[CH:17][NH:18][C:19]([CH:20]=2)=[C:15]34)=[CH:4][CH:3]=1.[ClH:35]>O1CCOCC1>[ClH:35].[NH2:27][C@H:9]([CH2:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[C:10]([NH:11][C:12]1[CH:13]=[C:14]2[C:24](=[O:25])[NH:23][N:22]=[CH:21][C:16]3=[CH:17][NH:18][C:19]([CH:20]=1)=[C:15]23)=[O:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136181672HCID 136181672, compound

Product 1

HCID 136341287HCID 136341287, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Preparation of example 194 from the title compound of Example 157 (48 mg, 0.10 mmol) and 4M HCl in dioxane (10 mL) was carried out analogously to Example 91. Isolation, also in an analogous manner afforded the title compound (34 mg, 0.08 mmol) as an orange/yellow powder in 80% yield.

Sources & evidence

ORD record
ord-3a5e515989c84c02baf01cce91f20916
Source dataset
uspto-grants-2006_11
Patent number
US07132533B2

Reaction notes

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