1,2-Dichloroethane → HCID 69587919, compound

HRID 720196Notes

Reaction equation

HRID 720196 reaction equation
[CH3:1][O:2][C:3](=[O:31])[CH:4]([NH:16][C:17](=[O:30])[CH:18]([NH:22]C(OC(C)(C)C)=O)[CH2:19][O:20][CH3:21])[CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=1.[Cl:32]CCCl>Cl.O1CCOCC1>[ClH:32].[CH3:1][O:2][C:3](=[O:31])[CH:4]([NH:16][C:17](=[O:30])[CH:18]([NH2:22])[CH2:19][O:20][CH3:21])[CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=1

Participants

5

Reactant 2

HCID 111,2-DichloroethaneHCID 69587788HCID 69587788, compound

Product 1

HCID 69587919HCID 69587919, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

2-(2-tert-butoxycarbonylamino-3-methoxy-propionylamino)-3-naphthalen-2-yl-propionic acid methyl ester, 57, (5.2 g, 12.1 mmol) is dissolved in 4M hydrogen chloride in dioxane (40 mL) and stirred at room temperature for 1 hour. 1,2-Dichloroethane (40 mL) is added. The solution is concentrated in vacuo to afford 4.43 g (quantitative yield) of the desired product.

Workup

  1. concentrationThe solution is concentrated in vacuo

Sources & evidence

ORD record
ord-7841b6fb40a94d13bd1f188b4e78662a
Source dataset
uspto-grants-2006_11
Patent number
US07132539B2

Reaction notes

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