Trifluoroacetic acid → HCID 21891665, compound

HRID 720253Notes

Reaction equation

HRID 720253 reaction equation
[F:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][NH:5][NH2:6].[C:12](/[CH:14]=[C:15](/[O-])\[C:16]([O:18][CH2:19][CH3:20])=[O:17])#[N:13].[Na+].FC(F)(F)C(O)=O>O1CCOCC1>[NH2:13][C:12]1[N:5]([CH2:4][C:3]2[CH:7]=[CH:8][CH:9]=[C:10]([F:11])[C:2]=2[F:1])[N:6]=[C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:14]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 21891668HCID 21891668, compoundHCID 60090632HCID 60090632, compound

Product 1

HCID 21891665HCID 21891665, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Preparation takes place in analogy to that described in Example 7 A from 1.50 g (9.48 mmol) of 1-(2,3-difluorobenzyl)hydrazine from Example 2 A, 1.55 g (9.48 mmol) of sodium (1E)-1-cyano-3-ethoxy-3-oxo-1-propen-2-olate from Example 6 A, 1.73 g (1.17 ml; 15.18 mmol) of trifluoroacetic acid and 40 ml of dioxane.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-fb62cbaf424148c5ab56a80c0d80e285
Source dataset
uspto-grants-2006_11
Patent number
US07135474B2

Reaction notes

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