Piperazine → HCID 21892117, compound

HRID 720424Notes

Reaction equation

HRID 720424 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:16](=[O:24])[C:17]2[CH:22]=[CH:21][C:20](F)=[CH:19][CH:18]=2)[N:6]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8][C:7]=12)#[N:2].[NH:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[C:1]([C:3]1[CH:4]=[C:5]([C:16](=[O:24])[C:17]2[CH:22]=[CH:21][C:20]([N:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)=[CH:19][CH:18]=2)[N:6]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8][C:7]=12)#[N:2]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 102676303-Cyano (4-fluoro-benzoyl)-pyrrolo[1,2-a]quinoline

Product 1

HCID 21892117HCID 21892117, compound

Procedure

The title compound was prepared as described for Example 21, using 3-cyano-(4-fluoro-benzoyl)-pyrrolo[1,2-a]quinoline ( 58 mg, 0.185 mmol) and piperazine (102 mg, 1.18 mmol), and yielded 57.2 mg (81%). 1H NMR (CDCl3): 8.01 (m, 3H), 7.80 (dd, J=7.8, 1.8 Hz, 1H), 7.64 (s, 2H), 7.52 (m, 2H), 7.34 (d, J=0.6 Hz, 1H), 6.60 (d, J=9.0 Hz, 2H), 3.41 (t, J=5.1 Hz, 4H 3.06 (t, J=4.5 Hz, 4H).

Workup

  1. customyielded 57.2 mg (81%)

Sources & evidence

ORD record
ord-58b6a0d2c28247e48b4603ec8fdd6b42
Source dataset
uspto-grants-2006_11
Patent number
US07135480B2

Reaction notes

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