反应详情

At RT 0.76 g (2 mmol) of 2-amino-4-(4-hydroxyphenyl)-6-sulfanyl-3,5-pyridinedicarbonitrile and 0.5 g (3 mmol) of N-ethylbromoacetamide are stirred in 5 ml of DMF together with 0.34 g (4 mmol) of NaHCO3 for 4 hours. After dilution with water, the mixture is extracted with ethyl acetate and the ethyl acetate phase is dried with MgSO4 and concentrated under reduced pressure. The solid residue obtained after concentration is stirred with methanol. The crystals are filtered off with suction and dried under reduced pressure.

1. extractionAfter dilution with water, the mixture is extracted with ethyl acetate
2. dry with materialthe ethyl acetate phase is dried with MgSO4
3. concentrationconcentrated under reduced pressure
4. customThe solid residue obtained
5. concentrationafter concentration
6. filtrationThe crystals are filtered off with suction
7. customdried under reduced pressure