Potassium cyanate → HCID 135828228, compound

HRID 720454Notes

Reaction equation

HRID 720454 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[C:5]([C:17]#[N:18])=[C:4]([S:19][CH2:20][CH2:21][NH2:22])[N:3]=1.[O-:23][C:24]#[N:25].[K+]>Cl.CO>[NH2:1][C:2]1[N:3]=[C:4]([S:19][CH2:20][CH2:21][NH:22][C:24]([NH2:25])=[O:23])[C:5]([C:17]#[N:18])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)[C:7]=1[C:8]#[N:9]

Participants

5

Reactant 2

HCID 11378442Potassium cyanateHCID 135828224HCID 135828224, compound

Product 1

HCID 135828228HCID 135828228, compound

Reagents, catalysts & solvents 2

HCID 887MethanolCatalystHCID 313Hydrochloric AcidSolvent

Conditions

Temperature
50 °C

Procedure

31.1 mg (0.1 mmol) of 2-amino-6-[(2-aminoethyl)sulfanyl]-4-(4-hydroxyphenyl)-3,5-pyridinedicarbonitrile are suspended in 0.91 ml of 1N HCl, and 8.1 mg (0.1 mmol) of potassium cyanate are added. After the addition of a few drops of methanol, the mixture is stirred at 50° C. for a total of 10 hours. The crystals are filtered off with suction and washed with water and ether.

Workup

  1. filtrationThe crystals are filtered off with suction
  2. washwashed with water and ether

Sources & evidence

ORD record
ord-3da9867df2ef47d6ba0c6f4eaec10340
Source dataset
uspto-grants-2006_11
Patent number
US07135486B1

Reaction notes

Loading…