Ammonia → HCID 69613552, compound

HRID 720470Notes

Reaction equation

HRID 720470 reaction equation
C[Sn](C)(C)[C:3]1[CH2:4][CH:5]2[CH2:9][CH2:8][N:7]([C:10]([O:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:11])[CH:6]2[CH:20]=1.Br[C:24]1[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=1.N>>[N:26]1[CH:27]=[CH:28][CH:29]=[C:24]([C:3]2[CH2:4][CH:5]3[CH2:9][CH2:8][N:7]([C:10]([O:12][CH2:13][C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)=[O:11])[CH:6]3[CH:20]=2)[CH:25]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 122863-BromopyridineHCID 21892828HCID 21892828, compound

Product 1

HCID 69613552HCID 69613552, compound

Procedure

The mixture of Example 38C (140 mg, 0.332 mmol) and 3-bromopyridine (0.042 mL, 0.43 mmol) were processed as described in Example 4C. Purification by chromatography (SiO2, 30% EtOAc/hexane) provided 90 mg (85%) of a 4:1 mixture of the title compounds. MS (DCI/NH3) m/z 321 (M+H)+.

Workup

  1. customPurification by chromatography (SiO2, 30% EtOAc/hexane)
  2. customprovided

Sources & evidence

ORD record
ord-075fa74c95874ad0b2628662f0d77499
Source dataset
uspto-grants-2006_11
Patent number
US07135484B2

Reaction notes

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