3-Bromopyridine → HCID 21892701, compound

HRID 720472Notes

Reaction equation

HRID 720472 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[O:8]=[C:9]1[C@@H:16]2[C@@H:12]([CH2:13][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:15]2)[CH2:11][CH2:10]1>>[C:20]([O:19][C:17]([N:14]1[CH2:15][CH:16]2[C:9]([OH:8])([C:2]3[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=3)[CH2:10][CH2:11][CH:12]2[CH2:13]1)=[O:18])([CH3:23])([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 122863-BromopyridineHCID 29948688rel-1,1-Dimethylethyl (3aR,6aS)-hexahydro-4-oxocyclopenta[c]pyrrole-2(1H)-carboxylate

Product 1

HCID 21892701HCID 21892701, compoundYield 27%

Procedure

3-Bromopyridine (4.36 g, 27.6 mmol) and the product from Example 44A (2.07 g, 9.19 mmol) were processed as described in Example 1E to afford the title compound (0.743 g, 27%). MS (DCI/NH3) m/z 305 (M+H)+.

Sources & evidence

ORD record
ord-6caac7f76e4848cc80d8020d32b82c90
Source dataset
uspto-grants-2006_11
Patent number
US07135484B2

Reaction notes

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