Lithium borohydride → HCID 10005328, compound

HRID 720616Notes

Reaction equation

HRID 720616 reaction equation
C[O:2][C:3](=O)[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[N:14]=[C:13]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:26])[CH3:25])=[CH:19][CH:18]=3)[NH:12][C:11]=2[C:10](=[O:27])[N:9]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[F:35])[C:8]1=[O:36].[BH4-].[Li+]>O1CCCC1>[F:35][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=1[CH2:28][N:9]1[C:10](=[O:27])[C:11]2[NH:12][C:13]([CH2:16][C:17]3[CH:18]=[CH:19][C:20]([NH:23][C:24](=[O:26])[CH3:25])=[CH:21][CH:22]=3)=[N:14][C:15]=2[N:7]([CH2:6][CH2:5][CH2:4][CH2:3][OH:2])[C:8]1=[O:36]

Participants

4

Reactant 2

HCID 4148881Lithium borohydrideHCID 11755954HCID 11755954, compound

Product 1

HCID 10005328HCID 10005328, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by the reduction of 4-[8-(4-acetylamino-benzyl)-1-(2-fluorobenzyl)-2,6-dioxo-1,2,6,7-tetrahydro-purin-3-yl]-butyric acid methyl ester with lithium borohydride in tetrahydrofuran. The product was purified by chromatography on silica gel eluted with 9:1 chloroform/methanol. MS, m/z(M+)=479.1967.

Workup

  1. customThe product was purified by chromatography on silica gel
  2. washeluted with 9:1 chloroform/methanol

Sources & evidence

ORD record
ord-4033145014c24aeb97ec84a5f91311d2
Source dataset
uspto-grants-2006_11
Patent number
US07135475B2

Reaction notes

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