反应详情

This compound was prepared by a method similar to that described in example 79 except that 2,6-dimethoxynicotinic acid (Aldrich) was used in place of N-acetyl-6-amino-2-pyridine carboxylic acid, the reaction was performed using 1 equivalent of 3-cyclopropylmethyl-8-[4-(methylamino)-benzyl]-1-(2-fluorobenzyl)-3,7-dihydropurine-2,6-dione and excess triethylamine and a catalytic amount of 4-dimethylaminopyridine were added as the final reagents to the reaction mixture. The product was purified by chromatography using silica gel eluted with 9:1 ethyl acetate/hexanes followed by crystallization from acetonitrile. MS, m/z(M+)=599.2417.

1. customThis compound was prepared by a method similar to
2. customThe product was purified by chromatography
3. washeluted with 9:1 ethyl acetate/hexanes
4. customfollowed by crystallization from acetonitrile