反应详情

Mono-methyl hexadecandioate (275 mg, 0.91 mmol) was dissolved in THF (3 ml) and treated with succinimidyl tetramethyluroniumtetrafluoroborate (331 mg, 1.1 mmol) and N,N-diisopropylethylamine (188 μL, 1.1 mmol), and the mixture was stirred for 20 hours. The solvent was removed in vacuo, and the residue was dissolved in ethyl acetate and washed with 0.1 M HCl (twice) and water. The organic phase was dried over MgSO4, filtered and evaporated in vacuo to give 350 mg (96%) of methyl succinimidyl hexadecandioate.

1. customThe solvent was removed in vacuo
2. dissolutionthe residue was dissolved in ethyl acetate
3. washwashed with 0.1 M HCl (twice) and water
4. dry with materialThe organic phase was dried over MgSO4
5. filtrationfiltered
6. customevaporated in vacuo