反应详情

温度

110 °C

A solution (1.53M) of the product of step 1 in DMF was treated with SOCl2 (1 eq) and heated at 110° C. After 1.5 hours, the reaction mixture was cooled and poured into aqueous HCl (1 N). The resulting precipitate was filtered and washed with H2O and Et2O. The dried solid contained predominantly the title compound as a mixture with 6-methoxyquinoxaline-2,3-diol and 2,3-dichloro-6-methoxyquinoxaline. This material was used directly in the subsequent step. MS (ES+) m/z 211 (M+H)+

1. temperaturethe reaction mixture was cooled
2. filtrationThe resulting precipitate was filtered
3. washwashed with H2O and Et2O