反应详情

4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (50 mg) was added to toluene (5 ml), and triethylamine (0.5 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (77 mg) in methylene chloride was then added thereto, and the mixture was heated under reflux for 10 min. Next, 2-heptanol (30 mg) was added thereto, and the mixture was further stirred with heating under reflux for 3 hr. A saturated aqueous sodium bicarbonate solution was added to stop the reaction, and the reaction solution was then extracted with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution, water, and saturated brine in that order. The extract was dried over sodium sulfate and was, then concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (25 mg, yield 31%).

1. temperaturethe mixture was heated
2. temperatureunder reflux
3. customto prepare a solution
4. temperaturethe mixture was heated
5. temperatureunder reflux for 10 min
6. temperaturewith heating
7. temperatureunder reflux for 3 hr
8. customthe reaction
9. extractionthe reaction solution was then extracted with chloroform
10. washby washing with a 1 N aqueous hydrochloric acid solution, water, and saturated brine in that order
11. dry with materialThe extract was dried over sodium sulfate
12. concentrationconcentrated
13. customThe residue was purified on a column