反应详情

A solution of 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid methyl ester (5.0 g) in DMF (30 μL) was mixed with dimethoxymethyldimethylamine (5 mL) and stirred for 36 hours. The reaction solution was partitioned between water and ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated. The product with the molecular weight of 322.82 (C15H15ClN2O2S) was obtained in this way; MS (ESI): 323 (M+H+).

1. customThe reaction solution was partitioned between water and ethyl acetate
2. dry with materialThe organic phase was dried over magnesium sulfate
3. concentrationconcentrated
4. customThe product with the molecular weight of 322.82 (C15H15ClN2O2S) was obtained in this way